WebJun 14, 2005 · Michelle Gazdik, Kate E. Jarman, Matthew T. O’Neill, Anthony N. Hodder, Kym N. Lowes, Helene Jousset Sabroux, Alan F. Cowman, Justin A. Boddey, Brad E. Sleebs. Exploration of the P 3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V. Bioorganic & Medicinal Chemistry 2016 , 24 (9) … WebHelene Jousset Head of the Screening Laboratory Walter and Eliza Hall Institute of Medical Research. Outline • National Drug Discovery Centre overview • Our capabilities • How …

Exploration of the P3 region of PEXEL peptidomimetics leads to a …

WebMar 4, 2024 · A novel class of antimalarial compounds that can effectively kill malaria parasites has been developed. In preclinical testing, the compounds were effective against different species of malaria ... WebMichelle Gazdik, Kate E. Jarman, Matthew T. O'Neill, Anthony N Hodder, Kym N Lowes, Helene Jousset Sabroux, Alan Frederick Cowman, Justin A Boddey, Brad E Sleebs Research output : Contribution to journal › Article › Research › peer-review cotswold newspaper

Exploration of the P3 region of PEXEL peptidomimetics leads to a …

WebCa(2+) entry in endothelial cells is a key signaling event as it prolongs the Ca(2+) signal activated by a receptor agonist, and thus allows an adequate production of a variety of … WebHélène JOUSSET of University of Strasbourg, Strasbourg (UNISTRA) Contact Hélène JOUSSET WebA high-throughput screen for inhibitors of the histone acetyltransferase, KAT6A, led to identification of an aryl sulfonohydrazide derivative (CTX-0124143) that inhibited KAT6A with an IC 50 of 1.0 μM. Elaboration of the structure-activity relationship and medicinal chemistry optimization led to the discovery of WM-8014 (97), a highly potent inhibitor of KAT6A (IC … cotswold nextdoor