Crystallin promoter

Author: rncy

August undefined, 2024

WebSox-1 transactivated the γF-crystallin promoter in a dose-dependent fashion, similar to c-Maf (Fig. 2 C). Sox-1 also stimulated the βB2 promoter, but less strongly than c-Maf (Fig. 2 B). Prox-1 (80 ng) stimulated the βB2- and γF-crystallin promoters only about 2-fold (Fig. 2, B and C). To determine whether these transcription factors can ...

Regulation of αA‐crystallin via Pax6, c‐Maf, CREB and a broad …

WebCrystallins are a diverse group of abundant soluble proteins that are responsible for the refractive properties of the transparent eye lens. We showed previously that Pax-6 can activate the αB-crystallin/small heat shock protein promoter via the lens-specific regulatory regions LSR1 (−147/−118) and LSR2 (−78/−46). WebJul 1, 2002 · It is proposed that Pax6 occupies and represses the chicken βB1-crystallin promoter in lens epithelial cells, and is displaced by Prox1 and Mafs, which activate the promoter, in differentiating cortical fiber cells. ... It is shown that the transactivation potential of c-Maf and MafB for the rat gammaD-crystallin Maf-responsive element (gammaD ... blastoise 2012

Sequence determinants of human gene regulatory elements

WebCrestline serves sophisticated institutions, family offices and high-net-worth individuals in North America, Europe and Asia who seek innovative alternative investment solutions … WebSep 1, 2002 · These data suggest that the chicken β B1-crystallin promoter is the promoter of choice to direct the high level ectopic expression of RNAs to lens fiber cells … Web300bp Human Beta B1 crystallin promoter. Availability. Academic Institutions and Nonprofits only Enlarge mEos2-Talin-N-22. Plasmid #57420. Purpose. Localization: Focal Adhesions, Excitation: 505 / 569, Emission: 516 / 581. Depositor. Michael Davidson. Article. Kanchanawong et al Nature. 2010 Nov 25;468(7323):580-4. doi ... blastoise 25th anniversary value

Characterization of the chicken L‐Maf, MafB and c‐Maf in crystallin ...

WebCrystallin promoters of widely different species are dependent on the same suite of transcription factors and function in similar ways in lens-cells of other species both in culture and in transgenic models (for example: [31–33]). This allows comparison of promoters from both chicken and mouse in mouse cells. WebNov 3, 2003 · In order to identify PaxB response elements in the J3-crystallin promoter, we generated a series of J3 promoter deletions in the luciferase reporter construct. The shortest promoter fragment, consisting of only 200 bp upstream of the transcriptional start site, was activated by PaxB and not by PaxB(I84R) (data not shown; but cf. Figure 5C ) . blastoise 2/102WebRegulation of Mouse Small Heat Shock Protein alpha b-Crystallin Gene by Aryl Hydrocarbon Receptor. Author: Liu, S. A. L. S. A. Piatigorsky, J. Author Address blastoise 31/149 2012

"WebThe crystallin genes are expressed at relatively low levels in many other tissues besides lens, where they apparently function in various ways in stress amelioration; thus for example, the α-crystallin family of lens proteins is similar to the small heat shock proteins, and one of these genes responds directly to a xenobiotic response factor … " - Crystallin promoter

Crystallin promoter

CREB-binding Protein/p300 Co-activation of Crystallin Gene …

WebThe human papillomavirus type 16 (HPV-16) E6 and E7 oncogenes are thought to play a role in the development of most human cervical cancers. These E6 and E7 oncoproteins affect cell growth control at least in part through their association with and WebJul 15, 1992 · Progeny from two of these lines were mated with transgenic mice expressing the Cre recombinase under control of either the murine alpha A-crystallin promoter or …

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WebA conserved and essential DNA motif in the promoters of the γ-crystallin genes is the binding site of the SOX proteins that activate the promoters (Kamachi et al., 1995). … WebJan 15, 2000 · Many of the crystallin promoters have been carefully dissected into component cis -acting elements with critical regions and putative transcription factor binding sites identified ( Cvekl and Piatigorsky, 1996; Duncan et al., 1996; Matsuo et al., 1991 ).

WebThis study concluded that there existed a TGF-β responsive element in the promoter just 285 base pairs upstream of the transcriptional start site ... porcine TGF-β1 under the lens-specific αA-crystallin promoter and then another similar line was created but with the gene driven by the βb-crystallin promoter, corresponding to another lens ... WebIn anatomy, a crystallin is a water-soluble structural protein found in the lens and the cornea of the eye accounting for the transparency of the structure. It has also been …

WebMay 4, 2006 · Dramatic upregulation of αA-crystallin expression is associated with primary lens fiber cell differentiation. Previous studies have shown that a −366 to +46 αA … WebPromoter methylation of RASEF was associated with increased risk of death due to metastasis, ... Epigenetic regulation of αA-crystallin in high myopia-induced dark nuclear cataract. PLoS One 2013; 8: e81900. doi: 10.1371/journal.pone.0081900. 8. Mao W, Rubin JS, Anoruo N, Wordinger RJ, Clark AF.

WebThe beta-B1 crystallin promoter produced GFP expression in the lenses of 37% of injected embryo’s after 48 hours. Fifty percent of MO injected …

WebThe two paralogous zebrafish αB-crystallin promoters produced subtly different expression profiles, with the aBa promoter driving expression equally in notochord and skeletal muscle while the αBb promoter resulted primarily in skeletal muscle expression. blastoise 36/165WebMar 21, 2024 · Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell … blastoise 4/165 holoWebProx1 activates several of the different crystallin promoters, and acts synergistically with another lens transcription factor, Maf, to activate transcription of ß1 and ß2 crystallins (Lengler ... blastoise attacksWebDec 3, 2013 · CpG island methylation in the αA-crystallin promoter was similar in age-related cataract and high-myopic cataract classified as Lens Opacity Classification System III Grade Nuclear Color 2–3. Pyrosequencing, a real-time DNA sequencing method, was used to determine single-base variations caused by CpG methylation of the CRYAA … blastoise 2/132 holoWebDec 29, 2008 · The scallop Ω-crystallin promoter sequence contains an abundance of motifs that are similar to those in vertebrate crystallin promoters. These include cis … blastoise evolution levelWebApr 8, 2024 · Among the 14 crystallin genes that human and mouse have in common, mRNA levels of Crybb1, Crygd, Cryba2, Cryba4, Crybb3, Cryga, and Crygs were significantly up-regulated in myopic eyes of... blastoise ex valueWebSep 1, 2002 · Thus, the chicken betaB1-crystallin promoter directs high level RNA expression to lens fiber cells, which may be especially useful for the expression of ribozyme and anti-sense RNAs in addition to ... blastoise ex 21/108 value