Cisplatin efficacy
WebCisplatin is a widely used cytotoxic agent approved in the treatment of bladder, ovarian, testicular, cervical, head and neck, and nonsmall cell lung cancer [ 1 – 3 ]. Cisplatin was first documented in 1847 by M. Peyrone, and it was approved by FDA for a variety of cancers in 1978. WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, …
Cisplatin efficacy
Did you know?
WebApr 11, 2024 · Importantly, inhibition of STAT3 signaling significantly attenuated MB tumor growth in subcutaneous and intracranial orthotopic xenografts, increased the sensitivity of MB tumors to cisplatin, and improved the survival of … WebOct 5, 2014 · Cisplatin is cleared by the kidney by both glomerular filtration and tubular secretion (Yao, Panichpisal et al., 2007; Ishida, Lee et al., 2002) Cisplatin …
WebApr 15, 2024 · A 64-year-old man exhibited lack of efficacy during treatment with pirarubicin, gemcitabine and cisplatin for metastatic, high-grade non-muscle invasive bladder urothelial carcinoma. Additionally, he also developed severe dizziness, nausea and vomiting during treatment with gemcitabine and cisplatin for metastatic high-grade non … WebNov 22, 2024 · 1:1 randomization between cisplatin alone, and cisplatin, sodium thiosulfate and mannitol. Masking: Single (Outcomes Assessor) Primary Purpose: Prevention: Official Title: A Multicenter Randomized Phase II Clinical Trial of the Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving …
WebApr 11, 2024 · To evaluate if STAT3 KD can enhance the efficacy of cisplatin therapy for MB, we treated HD-shSTAT3 and ONS-shSTAT3 cells with an increasing concentration … WebSep 15, 2024 · Cisplatin has activity against multiple tumor types and was approved for use by the United States in 1978. Current indications include testicular, ovarian and bladder cancer. It is also used in combination with other agents in …
WebSep 27, 2016 · PURPOSE Paclitaxel, ifosfamide, and cisplatin (TIP) achieved complete responses (CRs) in two thirds of patients with advanced germ cell tumors (GCTs) who relapsed after first-line chemotherapy with cisplatin and etoposide with or without bleomycin. We tested the efficacy of first-line TIP in patients with intermediate- or poor …
WebSep 20, 2024 · Efficacy was evaluated in two multicenter open-label, randomized controlled trials in pediatric patients undergoing treatment with cisplatin-based chemotherapy for … phish tela lyricsWebJan 13, 2024 · Indeed, after decades of research on antioxidants optimized for scheduling, dose, potency, and method of administration, no antioxidant therapy has demonstrated enough efficacy to be widely accepted as a therapy for cisplatin ototoxicity. Despite some limitations of antioxidants, several have moved toward a clinical trial. phish tattoo designsWebFeb 1, 2024 · Cisplatin injection is used to treat advanced cancer of the bladder, ovaries, or testicles. Cisplatin is an antineoplastic agent (cancer medicine). It … phish tech kansas citytss-15WebClinical Comparative Investigation of Efficacy and Toxicity of Cisplatin plus Clinical comparative investigation of efficacy and toxicity of cisplatin plus gemcitabine or plus … phish the curtain lyricsWebChemotherapeutics that damage DNA, such as cisplatin, have been the mainstay of cancer treatment for decades . However, all too often the efficacy of such DNA-damaging chemotherapy is severely limited by intrinsic and acquired drug resistance, as well as by the induction of secondary malignancies. phish tattoo ideasWebMar 15, 2024 · The incidence of ototoxicity induced by cisplatin has been estimated to be 36% of adult patients with cancer and 40%-60% of pediatric patients.2 … tss1500