Cisplatin and kidney damage

Author: ydkm

August undefined, 2024

WebCisplatin dose adjustment in patients with renal impairment must be improved. Estimating GFR with the aMDRD formula and adding an intermediary level of dose reduction for patients with eGFR from 50 to 59.9 mL/min may result in a higher cumulative dose of cisplatin without higher renal toxicity, whic … WebAlthough it is best known for DNA damage, cisplatin also causes cytoplasmic organelle dysfunction particularly with the endoplasmic reticulum and mitochondria. It also activates apoptotic pathways and inflicts cellular damage via oxidative stress and inflammation. One of its dose limiting toxicities is its effects on the kidney.

Molecular mechanisms of cisplatin-induced nephrotoxicity: a …

WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, … WebNov 12, 2024 · Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy.Nausea and Vomiting: cisplatin injection can cause severe … bubble bloodline shindo

Cumulative DNA damage by repeated low-dose cisplatin …

WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … WebMar 29, 2024 · In cisplatin-treated wildtype mice, there were increases in biomarkers of CIAKI, in addition to histological indication of kidney damage such as tubule dilation and … bubble bloodline shindo life

Pathophysiology of Cisplatin-Induced Acute Kidney Injury - Hindawi

Proposed mechanism for cisplatin/CYP450 dependent kidney damage…

WebTubular epithelial cells (TECs) is one of the most damaged cells in cisplatin induced AKI ( Xu et al., 2015 ). The well-known mechanism by which cisplatin exerts its anticancer effects—DNA damage—also affecting renal cells ( Tchounwou et al., 2024 ). WebJun 18, 2024 · Typical adverse reactions associated with cisplatin include kidney damage, high emetogenic potential, peripheral neuropathy, ototoxicity, and … explanatory note format dcaaWebMay 8, 2024 · Serum Creatinine (SCr)-Acute Kidney Injury (AKI) Staging Outlined by the Kidney Disease: Improving Global Outcomes (KDIGO) Guidelines and Electrolyte-AKI (eAKI) Grading Based on National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) Version 4 eTable 2. explanatory middle range theory

"WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and … " - Cisplatin and kidney damage

Cisplatin and kidney damage

The use of cisplatin in patients after kidney... : Medicine

Webing on pathologic examination of human kidneys affected by cisplatin toxicity. Both proximal and distaltubulesareaffected,andinpatientswithAKI, there is usually acute tubular necrosis. Long-term cisplatin exposure may also cause cyst formation and interstitial ﬁbrosis (Figure 1) (3). Patients with cisplatin toxicity typically present WebMay 8, 2024 · Nephrotoxicity With Cisplatin Patients may accumulate metabolites in the renal proximal tubule cells of the kidneys, where 90% of cisplatin undergoes urinary excretion, Duffy et al. explained. This causes a trifecta of factors: direct inflammation, production of reactive oxygen species leading to oxidative cell damage, and cell death.

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WebApr 12, 2024 · In the end, the kidney is heavily involved in the elimination of the drugs, and, as a consequence, kidney damage can lead to an altered excretion of the drugs and … WebThe prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal …

WebApr 12, 2005 · Oxaliplatin is an antitumoral agent derived from platinum (trans-1,2-diammino-cylo-hexane-platinum) with cytotoxic activity against a number of solid tumours, including colorectal cancer and metastatic ovarian carcinoma. Renal side-effects are unclear. We report the second case of acute renal failure following the use of oxaliplatin. WebDec 3, 2024 · One in four patients treated with cisplatin develop chronic kidney disease. The Yale researchers found that by using an agonist peptide, derived from the secreted …

WebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various intracellular stresses, including DNA damage,... Multiple stress responses, including … WebFeb 16, 2016 · In cisplatin-based CCRT schedules, acute nephrotoxicity is commonly graded by an increase of serum creatinine levels, according to the Common Terminology Criteria for Adverse Events (CTCAE). Using these criteria nephrotoxicity ≥grade 3 occurs in only 4%–9% of patients [ 7, 10, 11 ].

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WebDec 21, 2024 · Cisplatin is a potent first-line of chemotherapeutic drug for treating various neoplasms, but its administration in hospital settings is hampered due to its untoward nephrotoxicity. Previous investigations indicated that about 30% of cisplatin-treated patients (at the dose of 50–100 mg/m 2) developed AKI [ 7 ]. bubbleblood respawn timerWebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has … bubble block terrariaWebApr 14, 2024 · For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [ 29, 30 ]. In addition, nicotinamide prevents apoptosis in different cellular injury paradigms [ 31 ]. bubble bloom coWebAug 6, 2014 · The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease. The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, oxidative stress, inflammation, and vascular injury in the kidney. explanatory note form b 2021WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and neck, bladder, ovarian, and testicular malignanc Cisplatin-Induced Acute Kidney Injury and Renal Salt Wasting Syndrome Federal Practitioner bubble blossom where to buyWebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported, the role of phosphate in the cisplatin-induced CKD progression is not described. explanatory note gc.caWebOct 22, 2024 · As repeated injections of 6 mg/kg cisplatin in a one-week interval did not cause apparent kidney injury and those of 10 mg/kg cisplatin accelerated kidney injury without causing lethality,... bubble blower gun